Simmons anchors Tennessee’s interior rush and becomes the focal point if Key’s edge presence is diminished. His pressure and run defense will be critical to keeping Arizona's offense in check while the Titans seek a comeback win.

Simmons has a prime matchup against a Cardinals line depleted by injuries, offering Tennessee a clear path to interior push and QB disruption.

Simmons faces a Cardinals interior line under duress; the six-sack performance last week hints at a favorable matchup for Simmons to disrupt the pocket and rack fantasy-worthy sacks, especially if Arizona leans on quick drops and misthrows.

Simmons is Full after rest, bolstering Titans’ defensive line presence and potentially improving fantasy outputs for the Titans’ defenders and limiting opponents’ rushing efficiency.

Simmons returned to full participation, restoring the Titans' interior pressure and run defense; fantasy managers should expect a healthy snap count and steady DL production if conditioning remains solid.